Monthly Archives: December 2013

Humor

A friend who’s in liquor production,
Has a still of astounding construction,
The alcohol boils,
Through old magnet coils,
He says that it’s proof by induction.

A chemistry teacher is recruited as a radio operator in the first world war. He soon becomes familiar with the military habit of abbreviating everything. As his unit comes under sustained attack, he is asked to urgently inform his HQ. “NaCl over NaOH! NaCl over NaOH!” he says. “NaCl over NaOH?” shouts his officer. “What do you mean?” “The base is under a salt!” came the reply.

A mosquito was heard to complain
That chemists had poisoned her brain.
The cause of her sorrow
Was para-dichloro-
diphenyl-trichloroethane.

There are two types of people in the world:
Those that can extrapolate from incomplete data

Many more, collected in the Guardian (UK)

The thermogelling PLGA–PEG–PLGA block copolymer as a sustained release matrix of doxorubicin – Biomaterials Science RSC Publishing

This study is aimed at extending a thermo-induced physical hydrogel as a localized delivery system of the antitumor drug doxorubicin DOX. An amphiphilic triblock copolymer consisting of polylactic acid-co-glycolic acid PLGA and polyethylene glycol PEG was synthesized. The PLGA–PEG–PLGA triblock copolymer/water system exhibited a reversible sol–gel transition with increasing temperature, and the gel window covered the physiological temperature 37 °C. After a subcutaneous injection of the aqueous polymer solution into Sprague–Dawley rats, in situ gelling occurred, and the gel persisted over 20 days in the body. The addition of DOX did not alter the basic thermogelling property, yet our rheological measurements revealed that the increased viscosity of the sol state influenced the available drug concentration, which should be taken into consideration with respect to the injectability. Despite being a small molecule and a water-soluble drug, DOX with an appropriate drug concentration was released from the physical hydrogel in a sustained manner following an initial burst. To evaluate antitumor efficacy in vivo, the formulation was injected subcutaneously into mice bearing sarcoma-180 solid tumors. A single injection of the DOX-loading gel presented higher therapeutic efficacy and lower toxic effects compared to two injections of free DOX under the same total dose.

via The thermogelling PLGA–PEG–PLGA block copolymer as a sustained release matrix of doxorubicin – Biomaterials Science RSC Publishing.